In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.
Identifieur interne : 000739 ( Main/Exploration ); précédent : 000738; suivant : 000740In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.
Auteurs : R Kanyanga Cimanga [Belgique] ; S Lumpu Nsaka ; M Ehata Tshodi ; B Maya Mbamu ; C Munduku Kikweta ; F Bool-Miting Makila ; Paul Cos [Belgique] ; Louis Maes [Belgique] ; Arnold J. Vlietinck [Belgique] ; Vassiliki Exarchou [Belgique] ; Emmy Tuenter [Belgique] ; Luc Pieters [Belgique]Source :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2019.
Descripteurs français
- KwdFr :
- Alstonia, Animaux, Antipaludiques (pharmacologie), Antipaludiques (usage thérapeutique), Composés phytochimiques (analyse), Composés phytochimiques (pharmacologie), Composés phytochimiques (usage thérapeutique), Extraits de plantes (), Extraits de plantes (pharmacologie), Extraits de plantes (usage thérapeutique), Humains, Lignée cellulaire, Paludisme (parasitologie), Paludisme (traitement médicamenteux), Parasitémie (parasitologie), Parasitémie (traitement médicamenteux), Plasmodium (), Racines de plante, Souris, Écorce.
- MESH :
- analyse : Composés phytochimiques.
- parasitologie : Paludisme, Parasitémie.
- pharmacologie : Antipaludiques, Composés phytochimiques, Extraits de plantes.
- traitement médicamenteux : Paludisme, Parasitémie.
- usage thérapeutique : Antipaludiques, Composés phytochimiques, Extraits de plantes.
- Alstonia, Animaux, Extraits de plantes, Humains, Lignée cellulaire, Plasmodium, Racines de plante, Souris, Écorce.
English descriptors
- KwdEn :
- Alstonia, Animals, Antimalarials (pharmacology), Antimalarials (therapeutic use), Cell Line, Humans, Malaria (drug therapy), Malaria (parasitology), Mice, Parasitemia (drug therapy), Parasitemia (parasitology), Phytochemicals (analysis), Phytochemicals (pharmacology), Phytochemicals (therapeutic use), Plant Bark, Plant Extracts (chemistry), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Roots, Plasmodium (drug effects).
- MESH :
- chemical , analysis : Phytochemicals.
- chemical , chemistry : Plant Extracts.
- chemical , pharmacology : Antimalarials, Phytochemicals, Plant Extracts.
- chemical , therapeutic use : Antimalarials, Phytochemicals, Plant Extracts.
- drug effects : Plasmodium.
- drug therapy : Malaria, Parasitemia.
- parasitology : Malaria, Parasitemia.
- Alstonia, Animals, Cell Line, Humans, Mice, Plant Bark, Plant Roots.
Abstract
An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.
DOI: 10.1016/j.jep.2019.02.019
PubMed: 30763695
Affiliations:
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Le document en format XML
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Box 212, Kinshasa XI, Democratic Republic of Congo; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. Electronic address: kanyanga.cimanga@uantwerpen.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><wicri:noRegion>B-2610 Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Nsaka, S Lumpu" sort="Nsaka, S Lumpu" uniqKey="Nsaka S" first="S Lumpu" last="Nsaka">S Lumpu Nsaka</name><affiliation><nlm:affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation><wicri:noCountry code="subField">Democratic Republic of Congo</wicri:noCountry></affiliation></author><author><name sortKey="Tshodi, M Ehata" sort="Tshodi, M Ehata" uniqKey="Tshodi M" first="M Ehata" last="Tshodi">M Ehata Tshodi</name><affiliation><nlm:affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation><wicri:noCountry code="subField">Democratic Republic of Congo</wicri:noCountry></affiliation></author><author><name sortKey="Mbamu, B Maya" sort="Mbamu, B Maya" uniqKey="Mbamu B" first="B Maya" last="Mbamu">B Maya Mbamu</name><affiliation><nlm:affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation><wicri:noCountry code="subField">Democratic Republic of Congo</wicri:noCountry></affiliation></author><author><name sortKey="Kikweta, C Munduku" sort="Kikweta, C Munduku" uniqKey="Kikweta C" first="C Munduku" last="Kikweta">C Munduku Kikweta</name><affiliation><nlm:affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation><wicri:noCountry code="subField">Democratic Republic of Congo</wicri:noCountry></affiliation></author><author><name sortKey="Makila, F Bool Miting" sort="Makila, F Bool Miting" uniqKey="Makila F" first="F Bool-Miting" last="Makila">F Bool-Miting Makila</name><affiliation><nlm:affiliation>Departement of Pharmacology and Pharmacovigilance, Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</nlm:affiliation><wicri:noCountry code="subField">Democratic Republic of Congo</wicri:noCountry></affiliation></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. Vlietinck</name><affiliation wicri:level="4"><nlm:affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Exarchou, Vassiliki" sort="Exarchou, Vassiliki" uniqKey="Exarchou V" first="Vassiliki" last="Exarchou">Vassiliki Exarchou</name><affiliation wicri:level="4"><nlm:affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Tuenter, Emmy" sort="Tuenter, Emmy" uniqKey="Tuenter E" first="Emmy" last="Tuenter">Emmy Tuenter</name><affiliation wicri:level="4"><nlm:affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name><affiliation wicri:level="4"><nlm:affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alstonia</term><term>Animals</term><term>Antimalarials (pharmacology)</term><term>Antimalarials (therapeutic use)</term><term>Cell Line</term><term>Humans</term><term>Malaria (drug therapy)</term><term>Malaria (parasitology)</term><term>Mice</term><term>Parasitemia (drug therapy)</term><term>Parasitemia (parasitology)</term><term>Phytochemicals (analysis)</term><term>Phytochemicals (pharmacology)</term><term>Phytochemicals (therapeutic use)</term><term>Plant Bark</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Plant Roots</term><term>Plasmodium (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alstonia</term><term>Animaux</term><term>Antipaludiques (pharmacologie)</term><term>Antipaludiques (usage thérapeutique)</term><term>Composés phytochimiques (analyse)</term><term>Composés phytochimiques (pharmacologie)</term><term>Composés phytochimiques (usage thérapeutique)</term><term>Extraits de plantes ()</term><term>Extraits de plantes (pharmacologie)</term><term>Extraits de plantes (usage thérapeutique)</term><term>Humains</term><term>Lignée cellulaire</term><term>Paludisme (parasitologie)</term><term>Paludisme (traitement médicamenteux)</term><term>Parasitémie (parasitologie)</term><term>Parasitémie (traitement médicamenteux)</term><term>Plasmodium ()</term><term>Racines de plante</term><term>Souris</term><term>Écorce</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Phytochemicals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Phytochemicals</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Phytochemicals</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Composés phytochimiques</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term><term>Parasitemia</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Composés phytochimiques</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term><term>Parasitémie</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term><term>Composés phytochimiques</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alstonia</term><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Mice</term><term>Plant Bark</term><term>Plant Roots</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alstonia</term><term>Animaux</term><term>Extraits de plantes</term><term>Humains</term><term>Lignée cellulaire</term><term>Plasmodium</term><term>Racines de plante</term><term>Souris</term><term>Écorce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><noCountry><name sortKey="Kikweta, C Munduku" sort="Kikweta, C Munduku" uniqKey="Kikweta C" first="C Munduku" last="Kikweta">C Munduku Kikweta</name><name sortKey="Makila, F Bool Miting" sort="Makila, F Bool Miting" uniqKey="Makila F" first="F Bool-Miting" last="Makila">F Bool-Miting Makila</name><name sortKey="Mbamu, B Maya" sort="Mbamu, B Maya" uniqKey="Mbamu B" first="B Maya" last="Mbamu">B Maya Mbamu</name><name sortKey="Nsaka, S Lumpu" sort="Nsaka, S Lumpu" uniqKey="Nsaka S" first="S Lumpu" last="Nsaka">S Lumpu Nsaka</name><name sortKey="Tshodi, M Ehata" sort="Tshodi, M Ehata" uniqKey="Tshodi M" first="M Ehata" last="Tshodi">M Ehata Tshodi</name></noCountry><country name="Belgique"><noRegion><name sortKey="Cimanga, R Kanyanga" sort="Cimanga, R Kanyanga" uniqKey="Cimanga R" first="R Kanyanga" last="Cimanga">R Kanyanga Cimanga</name></noRegion><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><name sortKey="Exarchou, Vassiliki" sort="Exarchou, Vassiliki" uniqKey="Exarchou V" first="Vassiliki" last="Exarchou">Vassiliki Exarchou</name><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name><name sortKey="Tuenter, Emmy" sort="Tuenter, Emmy" uniqKey="Tuenter E" first="Emmy" last="Tuenter">Emmy Tuenter</name><name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. Vlietinck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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